Helicobacter pylori infection induced genome instability and gastric cancer
نویسندگان
چکیده
منابع مشابه
Helicobacter Pylori Infection and Gastric Cancer
Introduction The role played by infectious diseases in cancer causation is a timely subject. Infections are associated with some of the most prevalent cancers in the world, such as carcinomas of the stomach, liver, and cervix. Pisani et al. (1) estimates that 15% of malignant neoplasms that occur worldwide are attributable to infections that may be preventable. It is important that we share the...
متن کاملGastric cancer and Helicobacter pylori infection.
AIMS To identify differences in the prevalence of Helicobacter pylori infection in different groups of patients with gastric cancer. METHODS In total 224 cases of gastric cancer were studied: 120 (53.6%) intestinal; 69 (30.8%) diffuse; and 35 (15.6%) unclassified. Site of tumour, presence and severity of gastritis, presence and extent of intestinal metaplasia, and age and sex were also record...
متن کاملPresence of cagA Gene in Patients with Gastric Cancer and Gastritis with Helicobacter pylori Infection
Background and purpose: Helicobacter pylori is a gram-negative, micro-aerophilic, and spiral-shaped bacillus. Infection with this bacterium can lead to gastritis, ulcers, and even gastric cancer. This study was conducted to evaluate the presence of the cagA gene among patients with gastritis and gastric cancer. Materials and methods: This study was performed in patients with gastritis (n=40) a...
متن کاملProteolysis in Helicobacter pylori-Induced Gastric Cancer
Persistent infections with the human pathogen and class-I carcinogen Helicobacter pylori (H. pylori) are closely associated with the development of acute and chronic gastritis, ulceration, gastric adenocarcinoma and lymphoma of the mucosa-associated lymphoid tissue (MALT) system. Disruption and depolarization of the epithelium is a hallmark of H. pylori-associated disorders and requires extensi...
متن کاملAnalysis of KRAS gene mutation associated with Helicobacter pylori infection in patients with gastric cancer
Objective(s): KRAS proto-oncogene mutation can be considered a diagnostic factor for treating various malignancies. Helicobacter pylori infection, a risk factor for stomach cancer, may cause DNA damage and genetic changes. The aim of the current study was to assess the association of gastric cancer and KRAS mutation, demographic factors, and H. pylori infection.<...
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ژورنال
عنوان ژورنال: Genome Instability & Disease
سال: 2020
ISSN: 2524-7662
DOI: 10.1007/s42764-020-00010-1